Several US states have legalized the recreational use of marijuana and New York is poised to follow suit. The shift in policy has significant public health implications, especially for adolescents, people at risk for addiction and other vulnerable populations. Dr. Reynolds, who has been at the forefront of efforts to address the opioid epidemic and has advised New York State on marijuana policy, will discuss experiences in states that have legalized marijuana, update participants on marijuana research efforts, including medical use of the drug and discuss innovative clinical interventions for addressing marijuana dependence in young people.